Corrigendum: Targeted Temperature Management and Multimodality Monitoring of Comatose Patients After Cardiac Arrest

Targeted temperature management for comatose survivors of cardiac arrest.

n engl j med 363;13 nejm.org september 23, 201

Targeted Temperature Management (TTM) for Comatose Survivors of Cardiac Arrest

Animal data has long supported the concept of managing temperature by inducing hypothermia following cardiac arrest to improve neurological outcome. In 2002 two landmark trials were published in the New England Journal of Medicine (NEJM); A European multicentre trial with a total of 136 patients compared therapeutic hypothermia of 32-34 for 24 hours to normothermia and demonstrated 55% vs 39% f...

Targeted temperature management after cardiac arrest.

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Targeted Temperature Management after Cardiac Arrest

Prognostication of outcome after cardiac arrest and targeted temperature management

The vast majority of cardiac arrest (CA) survivors remain comatose at hospital arrival. Around one-half of these patients suffer from severe hypoxic encephalopathy leading to death or unresponsive wakefulness. Early outcome prognostication may reduce futile intensive care and suffering for next of kin. Several early prognostic markers have shown high positive predictive value for poor outcome i...